Lotta Vrang Selected Research

plasmepsin (plasmepsin I)

6/2005	Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
6/2004	Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.
8/2003	New inhibitors of the malaria aspartyl proteases plasmepsin I and II.
4/2003	New potent C2-symmetric malaria plasmepsin I and II inhibitors.
3/2003	Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II.

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Lotta Vrang Research Topics

Disease

5	Malaria 06/2005 - 03/2003
2	Acquired Immunodeficiency Syndrome (AIDS) 11/2004 - 04/2003
1	Hypertension (High Blood Pressure) 02/2012

Drug/Important Bio-Agent (IBA)

5	Peptide Hydrolases (Proteases)FDA Link 06/2005 - 03/2003
5	plasmepsin (plasmepsin I)IBA 06/2005 - 03/2003
3	statineIBA 06/2005 - 03/2003
2	Human immunodeficiency virus 1 p16 proteaseIBA 11/2004 - 04/2003
2	Aspartic Acid ProteasesIBA 06/2004 - 08/2003
1	Renin InhibitorsIBA 02/2012
1	aliskiren FDA Link 02/2012
1	SolutionsIBA 03/2003